GONCALVES Victor Voir la fiche profil en français

Since 2021 : Associate Professor (maître de conférences HDR) in Chemistry, Université de Bourgogne
2012-2021 : Assistant Professor (maître de conférences) in Chemistry, Université de Bourgogne
2009-2012 : Post-doctoral Research Associate in Medicinal Chemistry, Imperial College London; Groups of Dr Ed Tate and Pr Robin Leatherbarrow
2008-2009 : Post-doctoral Research Scientist in Medicinal Chemistry, Sanofi-Aventis, Toulouse - France with Alain Badorc and Jean-Pierre Maffrand

2021 :          Habilitation (HDR), Université Bourgogne Franche-Comté
2008 :          PhD in Medicinal Chemistry, University Paris Descartes, in the Group of Pr Nicolas Inguimbert and Michel Vidal
2005:           MRes (DEA) in Medicinal Chemistry, Pharmacology and Drug Metabolism, University Paris Descartes
2005 :          Ecole Nationale Supérieure de Chimie de Paris, Paris - (Chimie ParisTech)

FUNDING

France Life Imaging : "Echange d'expertise" (2021-2023; in collaboration with Dr Pierre-Simon Bellaye, CGFL, Dijon)
Région Bourgogne Franche-Comté : PhD fellowship - Romane Vizier (dispositif Itinéraire Chercheurs Entrepreneurs)
Conseil Régional de Bourgogne : 1-year Postdoctoral fellowship (2017-2018; Programme PARI II)
Agence Nationale pour la Recherche : Programme JCJC (2017-2022 ZINELABEL : Site-specific dual-labeling of proteins)
France Life Imaging : "Amorce de collaborations" (2017-2018; in collaboration with Dr Aurélie Prignon, Sorbonne Université, Paris)
Conseil Régional de Bourgogne : Programme PARI II (2016; Project 2-P5 with F. Denat: Synthesis and evaluation of novel peptide derivatives by PET/SPECT and multimodal imaging)
Cancéropôle Grand-Est : "Soutien à l’Emergence de Projets" (2016; Imaging of Hsp70)
Ministère ESR : PhD fellowship - Coline Canovas (2015-2018)
Conseil Régional de Bourgogne : Programme FABER (2013-2014; Peptides as targeting agents for nuclear imaging)

STUDENTS/POSTDOC

2023 : Marina BRAY et Alexandre CHARRA (L3 Chimie Dijon)
2022-2025 : Zoé BONNEFOY (PhD)
2022-2025 : Manon CARRIERRE (DUT Chimie Besançon + Apprentie Ingénieure Chimie Montpellier)
2022 : Maxime CHEVEAU (Master 2 T2MC Dijon)
2021-2024 : Jelena SALIEN (Joint PhD with Vrije Universiteit Brussel)
2021 : Youmna MOUTAA (Master 2 T2MC Dijon)
2021 : Johan FAIVRE (DUT Chimie Besançon)
2021 : Sara GONCALVES (Stage découverte 3ème)
2021 : Lauriane AVELINO, Edouard DALLOZ (L3 Chimie Dijon)
2020-2023 : Romane VIZIER (Master 2 T2MC + PhD)
2020 : Colin ROUANET (Stage découverte 3ème)
2019 : Thibaut CHARBONNIER (short term contract as Research engineer)
2019 : Isabelle WARNER (BS University Puget Sound)
2019-2022 : Thibaud BAILLY (Master 2 MMHD + PhD)
2017 : Laurène DA COSTA (Postdoc)
2017-2020 : Emma RENARD (PhD)
2017 : Alexis HERVEAUX (L2 SV Dijon), Mylène BONNIER (L3 Chimie Dijon)
2016 : Patrick DESIREE, Véronique TRAN (Licence 3 Dijon)
2015-2018 : Coline CANOVAS (Master 2 CMPP + PhD)
2014 : Camille ARBARERI (Master 2 CMPP)
2013 : Sébastien GALOIS (Master 2 CMPP)

ResearchGate

Google Scholar

Bibliography (March 2022)

27 - Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors
P. Adumeau, R. Raavé, M. Boswinkel, S. Heskamp, H.J.C.T. Wessels, A.J. van Gool, M. Moreau, C. Bernhard, L. Da Costa, V. Goncalves, F. Denat
Bioconjugate Chemistry (2022), 33, 3, 530–540

26 -  Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with ⁶⁸Ga-Labeled Antagonists: The Chelate Makes the Difference Again
E. Renard, M. Moreau, P.-S. Bellaye, M. Guillemin, B. Collin, A. Prignon, F. Denat, V. Goncalves
Journal of Medicinal Chemistry (2021), 64, 8564–8578

25 - Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tumors 
E. Renard, E. Collado Camps, C. Canovas, A. Kip, M. Gotthardt, M. Rijpkema, F. Denat, V. Goncalves, S.A.M. van Lith
Cancers (2021), 13, 428

24 - Design of Bimodal Ligands of Neurotensin Receptor 1 for PET Imaging and Fluorescence-Guided Surgery of Pancreatic Cancer
E. Renard, P.A. Dancer, C. Portal, F. Denat, A. Prignon, V. Goncalves
Journal of Medicinal Chemistry (2020), 63, 2426-2433

23 - Synthesis and evaluation of zirconium-89 labelled and long-lived GLP-1 receptor agonists for PET imaging
C.B. Jacobsen, R. Raavé, M.O. Pedersen, P. Adumeau, M. Moreau, I.E. Valverde, I. Bjørnsdottir, J.B. Kristensen, M.F. Grove, K. Raun, J. McGuire, V. Goncalves, S. Heskamp, F. Denat, M. Gustafsson
Nuclear Medicine and Biology (2020), 82-83, 49-56 

22 - Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for 89Zr-immunoPET
R. Raavé, G. Sandker, P. Adumeau, C. Borch Jacobsen, F. Mangin, M. Meyer, M. Moreau, C. Bernhard, L. Da Costa, A. Dubois, V. Goncalves, M. Gustafsson, M. Rijpkema, O. Boerman, J.-C. Chambron, S. Heskamp, F. Denat
European Journal of Nuclear Medicine and Molecular Imaging (2019), 46, 1966-1977

21 - Modular assembly of multimodal imaging agents through an inverse electron demand Diels-Alder reaction
C. Canovas, M. Moreau, J.-M. Vrigneaud, P.-S.Bellaye, B. Collin, F. Denat, V. Goncalves
Bioconjugate Chemistry (2019), 30, 888-897

20 - Site-Specific Near-Infrared Fluorescent Labelling of Proteins on Cysteine Residues with meso-Chloro-Substituted Heptamethine Cyanine Dyes
C. Canovas, P.-S. Bellaye, M. Moreau, A. Romieu, F. Denat, V. Goncalves
Organic & Biomolecular Chemistry (2018), 16, 8831-8836

19 - Site-Specific Dual-Labeling of Proteins on Cysteine Residues with Chlorotetrazines.
C. Canovas, M. Moreau, C. Bernhard, A. Oudot, M. Guillemin, F. Denat, V. Goncalves
Angewandte Chemie International Edition (2018), 57, 10646-10650

18 - 89Zr-immunoPET in oncology: state of the art 89Zr-radiochemistry.
S. Heskamp, R. Raavé, O.C. Boerman, M. Rijpkema, V. Goncalves, F. Denat
Bioconjugate Chemistry (2017), 28, 2211-2223

17 - Structure-guided optimization of quinoline inhibitors of Plasmodium N- myristoyltransferase 
V. Goncalves, J. A. Brannigan, A. Laporte, A. S. Bell, S. M. Roberts, A. J. Wilkinson, R. J. Leatherbarrow, E. W. Tate
MedChemComm (2017), 8, 191-197

16 - Direct subphthalocyanine conjugation to bombesin vs indirect conjugation to its lipidic nanocarrier 
Y. Bernhard, E. Gigot, V. Goncalves, M. Moreau, N. Sok, P. Richard, R.A. Decréau
Organic & Biomolecular Chemistry (2016), 14 (19), 4511-4518

15 - (R)-NODAGA-PSMA: A Versatile Precursor for Radiometal Labeling and Nuclear Imaging of PSMA-Positive Tumors 
E. Gourni, C. Canovas, V. Goncalves, F. Denat, P.T. Meyer, H.R. Maecke
PLoS One (2015), 10 (12), e0145755

14 - BODIPY-polyazamacrocycles as bimodal probes for molecular imaging
D. Lhenry, M. Larrouy, C. Bernhard, V. Goncalves, O. Raguin,P. Florent,M. Moreau,B. Collin,A. Oudot, J-M.Vrigneaud,F. Brunotte,C. Goze, F. Denat
Chemistry - A European Journal (2015), 21 (37), 13091-13099.

13 - MA-NOTMP: a triazacyclononane-trimethylphosphinate based bifunctional chelator for gallium-radiolabelling of biomolecules
S. Poty, P. Désogère, J. Šimeček, C. Bernhard, V. Goncalves, C. Goze, F. Boschetti, J. Notni, H.J. Wester, F. Denat
ChemMedChem (2015), 10, 1475-1479.

12 - Towards the elaboration of new gold-based optical theranostics
P-E. Doulain, R. Decréau, C. Racoeur, V. Goncalves, L. Dubrez, A. Bettaieb, P. Le Gendre, F. Denat, C. Paul, C. Goze, E. Bodio.
Dalton Transactions (2015), 44 (11), 4874-4883

11 - DMAP-BODIPY Alkynes: A Convenient Tool for Labeling Biomolecules for Bimodal PET–Optical Imaging
B. Brizet, V. Goncalves, C. Bernhard, P. D. Harvey, F. Denat, C. Goze.
Chemistry - A European Journal (2014), 20 (40), 12933-12944

10 - Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors
J.A. Hutton, V. Goncalves, J.A. Brannigan, D. Paape, M.H. Wright, T.M. Waugh, S.M. Roberts A.S. Bell, A.J. Wilkinson, D.F. Smith, R.J. Leatherbarrow, E.W. Tate.
Journal of Medicinal Chemistry (2014), 57 (20), 8664-8670

09 - Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: Screening, synthesis, and structural characterization of their binding mode
V. Goncalves, J.A. Brannigan, D. Whalley, B. Saxty, A.A. Holder, A.J. Wilkinson, E.W. Tate, R.J. Leatherbarrow.
Journal of Medicinal Chemistry (2012), 55 (7), 3578-3582

08 - A fluorescence-based assay for N-myristoyltransferase activity. 
V. Goncalves, J.A. Brannigan, E. Thinon, T.O. Olaleye, R. Serwa, S. Lanzarone, A.J. Wilkinson, E.W. Tate, R.J. Leatherbarrow
Analytical Biochemistry (2012), 421 (1), 342-344

07 - Targeting the pro-angiogenic VEGF-VEGFR protein-protein interface with drug-like compounds by in silico and in vitro screening 
B. Gautier, M.A. Miteva, V. Goncalves, F. Huguenot, C. Garbay, A. Lesnard, S. Rault, N. Inguimbert, Bruno O. Villoutreix, Michel Vidal
Chemistry & Biology (2011), 18 (12), 1631-1639

06 - Biochemical and structural analysis of the binding determinants of a vascular endothelial growth factor receptor peptidic antagonist 
B. Gautier, V. Goncalves, D. Diana, R. Di Stasi, F. Teillet, C. Lenoir, F. Huguenot, C. Garbay, R. Fattorusso, L. Domenico D'Andrea, M. Vidal, N. Inguimbert.
Journal of Medicinal Chemistry (2010), 53, 11, 4428-4440

05 - Total chemical synthesis of the D2 domain of human VEGF receptor 1
V. Goncalves, B. Gautier, F. Huguenot, P. Leproux, C. Garbay, M. Vidal, N. Inguimbert.
Journal of Peptide Science (2009), 15 (6), 417-422

04 - Structure-based design of a bicyclic peptide antagonist of the Vascular Endothelial Growth Factor Receptors
V. Goncalves, B. Gautier, C. Garbay, M. Vidal, N. Inguimbert.
Journal of Peptide Science (2008), 14 (6), 767-772

03 - On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition
V. Goncalves, B. Gautier, A. Regazzetti, P. Coric, S. Bouaziz, C. Garbay, M. Vidal, N. Inguimbert.
Bioorganic and Medicinal Chemistry Letters (2007), 17, 5590-5594

02 - Rational design, structure and biological evaluation of cyclic peptides mimicking the Vascular Endothelial Growth Factor
V. Goncalves, B. Gautier, P. Coric, S. Bouaziz, C. Lenoir, C. Garbay, M. Vidal, N. Inguimbert.
Journal of Medicinal Chemistry (2007), 50 (21), 5135-5146

01 - Development of a chemiluminescent screening assay for Vascular Endothelial Growth Factor Receptor 1 ligands
V. Goncalves, B. Gautier, C. Garbay, M. Vidal, N. Inguimbert.
Analytical Biochemistry (2007), 366 (1), 108-110

Patents
Plateforme tétrazine modulaire biocompatible - Victor Goncalves, Franck Denat, Claire Bernhard, Coline Canovas
FR 17 52451, FR 17 59851, PCT/EP2018/057520, WO2018172543A1

Organic Chemistry : Licence 2 Sciences de la Vie (SV), Licence 3 SV Parcours CUPGE

Peptide Chemistry and Bioconjugation Chemistry : Master T2MC, Master 2 Innovative Drugs